Figure 11

The functional link between Trx1 and CD30 is a very important step in the physiologic homeostasis and it underlines the big potentiality of these elements as clinical diagnostic and therapeutic targets. The results of the research explained that in addition to Trx1, sCD30 is also able to influence the CD30R capacity to mediate the activation of intracellular signals for immune system homeostasis and healthy longevity, thanks to the inhibition of the binding between CD30L and RCD30: Trx1 makes this function catalytically, modifying the stoichiometric structure of RCD30; sCD30 makes the same function binding and blocking the binding site of CD30L, with which it has a strong affinity. For these reasons they have both to be considered for the use of the RCD30 as immunological and therapeutic biomarkers, because Trx1 and sCD30 could both influence the capacity of CD30R to mediate the activation of intracellular signals.