Fig. 1From: Characteristics of spinal microglia in aged and obese mice: potential contributions to impaired sensory behaviorImpaired motor and sensory functions in adult obese, aged and aged obese mice. a) Body weight changes were observed in DIO mice, significantly increased in both DIO 6 and 17 month-mice compared to age-matched lean mice. (n = 6–8/group, ***p < 0.001, lean 6 vs. DIO 6, +++p < 0.001, lean 17 vs. DIO 17, ###p < 0.001, DIO 6 vs. DIO 17, xxx p < 0.001, lean 3 vs. lean 6, 17). b) Blood glucose levels were not significantly altered after long term high-fat diet (n = 6–8/group). c) Impaired motor coordination was observed in both DIO 6 and 17 month-mice, while lean 17 month-mice stayed less time on Rotarod. (n = 6–8/group, ***p < 0.001, lean 6 vs. DIO 6, +++p < 0.001, lean 17 vs. DIO 17,) d) Mechanical allodynia was reversed with aging (xxx p < 0.001, lean 3 vs. lean17) and with obesity in 6 month-mice (n = 6–8/group, *p < 0.05, lean 6 vs. DIO 6). e) Thermal hypersensitivity was observed in DIO 6 month-mice compared to lean 6 month-mice (n = 6–8/group, **p < 0.01, lean 6 vs. DIO 6) as well as in aged mice (n = 6–8/group, xx p < 0.01, xxx p < 0.001, lean 3 months vs. lean 6, 17 months). f) Cold hypersensitivity was detected in DIO 6 month-mice (n = 6–8/group, **p < 0.01, lean 6 vs. DIO 6), however, it was significantly reversed in DIO 17 month-mice (n = 6–8/group, +++p < 0.001, lean 17 vs. DIO 17, ###p < 0.001, DIO 6 vs. DIO 17)Back to article page