Fig. 3From: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodiesAnti-neo-epitope IgMs are present in the serum from other species than mice. Representative images of the hippocampal region of brain sections from 12-month-old ICR-CD1 mice simultaneously stained with Hoechst (blue), anti-MMP-2 antibody and rabbit (a), rat (b) and goat (c) serum. Clusters of granules can be observed with the anti-MMP-2 staining (red in a and c and green in b) and some granules of the clusters are stained with the different sera (green in a and c and red in b), which indicates that the serum of these species contained anti-neo-epitope IgMs. Scale bar: 50 μmBack to article page