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Table 3. Longitudinal associations between immunologic parameters, LTL and mtDNAcn with MCI (n=2,944)

From: Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Immunologic parameters

Model 1

Model 2

HR (95%CI)

P-value

HR (95%CI)

P-value

Platelet counts

1.001 (0.999, 1.003)

0.210

1.002 (1.000,1.003)

0.080

Neutrophil counts

1.012 (1.001, 1.024)

0.041

1.010 (0.998, 1.022)

0.094

Lymphocyte counts

0.985 (0.973, 0.997)

0.014

0.987 (0.975, 1.000)

0.045

Monocyte counts

1.353 (0.924, 1.982)

0.120

1.303 (0.887, 1.915)

0.178

SII

1.348 (1.100, 1.651)

0.004

1.333 (1.089, 1.633)

0.005

SIRI

1.601 (1.112, 2.304)

0.011

1.487 (1.024, 2.161)

0.037

LTL

0.851 (0.739, 0.980)

0.025

0.877 (0.761, 1.011)

0.070

mtDNAcn

0.827 (0.698, 0.979)

0.027

0.843 (0.712, 0.997)

0.046

  1. Note: Analyses were conducted using Cox proportional hazard regression. Model 1 was crude model; model 2 adjusted for sex, age, body mass index, smoking, alcohol consumption, hypertension, diabetes, hyperlipidemia and total PA and APOE ε4. Monocyte counts, SII and SIRI were logarithmically transformed.
  2. Abbreviations: MCI, mild cognitive impairment; HR, hazard ratio; CI, confidence interval; SII, systematic inflammation index; SIRI, systematic inflammation response index; LTL, leukocyte telomere length; mtDNAcn, mitochondrial DNA copy number