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Table 5. Nested case-control study on the associations of inflammatory cytokines, LTL, and mtDNAcn with MCI (n=153)

From: Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study

Biomarkers

Model 1

Model 2

OR (95%CI)

P-value

OR (95%CI)

P-value

IFN-γ

2.136 (1.413, 3.226)

<0.001

2.197 (1.401, 3.446)

0.001

IL-1β

1.503 (1.089, 2.074)

0.013

1.570 (1.099, 2.243)

0.013

IL-4

3.856 (1.068, 13.928)

0.039

4.335 (1.070, 17.565)

0.040

IL-6

3.091 (0.768, 12.437)

0.112

5.114 (1.091, 23.976)

0.038

IL-13

2.361 (1.443, 3.863)

0.001

2.314 (1.399, 3.827)

0.001

MCP-1

1.002 (0.999, 1.005)

0.223

1.001 (0.998, 1.005)

0.394

TNF-α

1.265 (1.130, 1.416)

<0.001

1.380 (1.186, 1.607)

<0.001

LTL

0.479 (0.248, 0.924)

0.028

0.421 (0.205, 0.868)

0.019

mtDNAcn

0.281 (0.120, 0.658)

0.003

0.269 (0.110, 0.656)

0.004

  1. Note: Nested case-control analysis was performed as a sensitivity analysis. Model 1 was crude model; model 2 adjusted for sex, age, body mass index, smoking, alcohol consumption and APOE ε4. IFN-γ, IL-1β, IL-4, IL-6 and IL-13 were logarithmically transformed.
  2. Abbreviation: MCI, mild cognitive impairment; OR, odds ratio; CI, confidence interval; IFN-γ, interferon-γ; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; TNF-α, tumor necrosis factor-α; LTL, leukocyte telomere length; mtDNAcn, mitochondrial DNA copy number
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Immunity & Ageing

ISSN: 1742-4933

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