Fig. 3

Association of risk of ≥40% eGFR decline with (A) recent thymic emigrants count, (B) proportion of recent thymic emigrants among CD4⁺ T cells, (C) proportion of CD28⁻ cells among CD4⁺ T cells, and (D) proportion of CD28⁻ cells among CD8⁺ T cells separately compared for CKD stages 1–3, 4, and 5. Models were constructed using Cox proportional hazards regression models with restricted cubic splines. There was no significant interaction in the risk of ≥40% eGFR decline for recent thymic emigrant count (RTEs), proportion of recent thymic emigrants among CD4⁺ T cells (RTE%), proportion of CD28⁻ cells among CD4⁺ T cells (CD28⁻/CD4⁺), and proportion of CD28⁻ cells among CD8⁺ T cells (CD28⁻/CD8⁺), irrespective of chronic kidney disease (CKD) stages 1–3, 4, and 5. Models were adjusted for age, sex, estimated glomerular filtration rate (eGFR) urinary protein, diabetes, and cytomegalovirus seropositive. Solid and dotted lines indicate log hazard ratios, and gray areas indicate 95% confidence intervals