Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults

Table 3 Associations of ccf-mtDNA with cognitive and physical outcomes adjusting for inflammatory biomarkers (N = 672)

Abbreviations: CI = Confidence interval; ccf-mtDNA = circulating cell-free mitochondrial DNA.
^aFrailty is composite variable consisting of grip strength, timed walk, body mass index and fatigue. Larger values correspond to higher frailty
^bMotor gait is a z-standardized composite variable comprised of walking time, walking steps, turning time, and turning steps. Larger values correspond to less time and fewer steps to complete task
^cMotor composite score is calculated using the following items: Purdue Pegboard Test, Finger-tapping test, Time to cover 8 feet, Number of steps required to cover 8 feet, 360 degree turn time, Number of steps to complete a 360 degree turn, Leg stand, Toe stand, Grip strength, Pinch strength. Larger values correspond to better functionality
Coefficients represent the difference in the outcome per 1000 copies per µL change in the ccf-mtDNA predictor on the log scale. Scores on cognition were t-standardized. Generalized estimating equations (GEE) were used to estimate association between ccf-mtDNA and cognitive and physical outcomes. Each coefficient was estimated from a separate GEE model. All models adjusted for baseline age, sex, race, education, baseline levels of CRP and sTNFR1. Bold indicates p < 0.05

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