| AGED |  | YOUNG |  |  | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Control | LPS | NP | Mi | PMA | CDN |  | Control | LPS | NP | Mi | PMA | CDN |  | Sig. Effects from GLM |
CD40L | 22.93  ± 7.39 | 17.59  ± 6.64 | 49.1  ± 34.28 | 42.23  ± 29.49 | 64.87  ± 46.26 | 21.05  ± 10.62 |  | 17.62  ± 8.46 | 17.53  ± 7.46 | 22.55  ± 11.36 | 19.25  ± 8.85 | 44.55  ± 14.04 | 16.28  ± 5.1 |  | -- |
EGF | 22.79  ± 6.17 | 21.95  ± 7.06 | 28.88  ± 4.85 | 24.53  ± 7.88 | 24.47  ± 8.03 | 22.27  ± 10.45 |  | 24.71  ± 2.95 | 28.55  ± 3.43 | 27.6  ± 2.77 | 24.64  ± 4.07 | 28.48  ± 3.94 | 26.29  ± 1.94 |  | -- |
CCL11 | 6.45  ± 1.73 | 8.84  ± 2.94 | 11.75  ± 2.07 | 7.24  ± 1.61 | 10.55  ± 1.34 | 8.6  ± 1.4 |  | 14.12  ± 2.55 | 13.92  ± 2.83 | 16.91  ± 2.06 | 12.91  ± 2.74 | 16.15  ± 2.91 | 16.68  ± 0.88 |  | Age * |
Flt3L | 0  ± 0 | 0.61  ± 0.61 | 0  ± 0 | 0.53  ± 0.53 | 0.7  ± 0.7 | 0  ± 0 |  | 1.44  ± 0.66 | 1.71  ± 0.64 | 1.78  ± 0.76 | 1.34  ± 0.73 | 2.64  ± 0.87 | 1.84  ± 0.63 |  | -- |
CX3CL1 | 22.93  ± 7.39 | 15.68  ± 0.74 | 30.57  ± 11.96 | 16.01  ± 3.07 | 22.82  ± 5.73 | 15.95  ± 5.65 |  | 15.96  ± 2.33 | 24.38  ± 4.16 | 20.92  ± 3.76 | 20.72  ± 5.58 | 34.07  ± 5.93 | 19.29  ± 4.3 |  | -- |
IL-1Ra | 10.17  ± 8.59 | 13.01  ± 11.52 | 25.63  ± 20.75 | 4.96  ± 3.27 | 8.29  ± 5.06 | 8.29  ± 5.94 |  | 122.79  ± 56.27 | 172.77  ± 71.95 | 88.98  ± 42.1 | 95.1  ± 38.41 | 62.09  ± 22.09 | 104.37  ± 35.73 |  | -- |
IL-3 | 0.79  ± 0.07 | 0.68  ± 0.08 | 1.02  ± 0.22 | 0.91  ± 0.2 | 4.23  ± 3.21 | 0.85  ± 0.07 |  | 0.82  ± 0.09 | 0.75  ± 0.09 | 0.95  ± 0.08 | 0.95  ± 0.13 | 64.77  ± 29.53 | 0.77  ± 0.11 |  | Trt * PMA > media |
IL-8 | 476.55  ± 438.1 | 1203.36  ± 1069.23 | 1273.92  ± 1255.38 | 203.16  ± 175.43 | 770.29  ± 651.71 | 313.76  ± 269.14 |  | 4851.7  ± 1632.21 | 3884.75  ± 1208.16 | 3363.05  ± 1097.72 | 3675.12  ± 1244.26 | 3570.11  ± 1166.03 | 4063.73  ± 1311.12 |  | Age * |
CCL2 | 605.93  ± 533.43 | 53.46  ± 39.91 | 420.6  ± 401.74 | 207.93  ± 166.66 | 105.99  ± 89.67 | 321.89  ± 244.61 |  | 2833.08  ± 880.65 | 1013.49  ± 537.84 | 2091.94  ± 904.24 | 2612.05  ± 823.35 | 1796.08  ± 735.31 | 2688.71  ± 855.83 |  | Age * |
CCL7 | 47.78  ± 41.39 | 1.74  ± 1.14 | 4.4  ± 3.41 | 21.91  ± 18.35 | 33.12  ± 30.27 | 36.77  ± 29.4 |  | 1364.98  ± 738.76 | 21.28  ± 8.61 | 23.72  ± 10.64 | 558.32  ± 228.69 | 243.31  ± 84.6 | 822.96  ± 402.48 |  | Age * |
CCL22 | 19.52  ± 3.57 | 24.33  ± 11.13 | 11.41  ± 5 | 17.51  ± 4.07 | 37.03  ± 15.05 | 12.88  ± 3.55 |  | 250.16  ± 107.1 | 152.63  ± 47.81 | 20.48  ± 5.34 | 191.65  ± 76.4 | 214.41  ± 86.02 | 271  ± 130.35 |  | Age * |
PGDF | 66  ± 23.08 | 54.95  ± 20.49 | 72.23  ± 37.4 | 76.5  ± 29.64 | 106.56  ± 49.73 | 67.24  ± 32.34 |  | 57.42  ± 15.05 | 54.97  ± 14.11 | 39.6  ± 12.84 | 59.69  ± 16.75 | 81.13  ± 21.61 | 53.02  ± 10.13 |  | -- |
CCL5 | 5039.57  ± 1003.87 | 6921.69  ± 2813.84 | 4102.32  ± 2079.83 | 5491.54  ± 1862.46 | 6944  ± 2721.11 | 4209.14  ± 1729.56 |  | 5474.51  ± 1262.09 | 5160.44  ± 594.57 | 2165.86  ± 782.96 | 5156.84  ± 1328.17 | 5769.67  ± 725.3 | 3331.47  ± 719.67 |  | Trt * NP<,media |
TGF-α | 0.78  ± 0.02 | 0.78  ± 0.06 | 0.79  ± 0.09 | 0.74  ± 0.05 | 0.73  ± 0.04 | 0.81  ± 0.07 |  | 1.07  ± 0.18 | 1.72  ± 0.38 | 0.93  ± 0.09 | 3.13  ± 2.26 | 0.92  ± 0.06 | 0.99  ± 0.14 |  | -- |
TNF-β | 0.08  ± 0.08 | 0.24  ± 0.1 | 0.2  ± 0.15 | 0.14  ± 0.09 | 0.99  ± 0.73 | 0.27  ± 0.14 |  | 0.54  ± 0.19 | 0.59  ± 0.16 | 0.82  ± 0.27 | 0.56  ± 0.2 | 7.13  ± 2.36 | 0.62  ± 0.17 |  | -- |
VEGF | 7.77  ± 6.8 | 12.23  ± 5.53 | 16.38  ± 9.52 | 7.24  ± 6.28 | 22.75  ± 8.28 | 4.44  ± 2.31 |  | 29.76  ± 9.77 | 44.37  ± 11.36 | 40.34  ± 13.08 | 32.14  ± 11.02 | 43.55  ± 5.13 | 28.78  ± 9.11 |  | Age†|