Fig. 1

Menopause enhances cytokine profile induction by endometrial antigen presenting cells. A Comparison of cytokine induction in co-culture of blood naïve T cells with allogeneic endometrial CD1a + DCs and (B) CD14 + cells isolated from premenopausal (n = 4) and postmenopausal patients (n = 10). Black dots represent blood naïve T cells alone. C Production of cytokines by CD14 + cells alone ( N = 4). D Comparison of proliferating T cell cytokine induction by CD1a + (n = 5) and CD14 + (n = 9) endometrial cells in co-culture. (D) Comparison of cytokine production in co-culture of blood naïve T cells with allogeneic endometrial antigen presenting cells (CD1a + (squares) and CD14 + (diamonds)) from pre (black) and postmenopausal women (white). Mann–Whitney U test was used to compare independent groups. *p < 0.05, **p < 0.01, ***p < 0.001