Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study

Table 2 Associations of accelerometer-assessed movement behaviors with plasma NfL concentration by daily sedentary behavior or physical activity time (n = 1,029)

Behavioral factors	β-coefficient (95% confidence interval), plasma NfL (pg/ml), log-transformed
Behavioral factors	Model 1^a	Model 2^a	Model 3^a
Daily SB time, hours
< 8.00 (n = 478)	-0.008 (-0.043, 0.027)	-0.005 (-0.040, 0.030)	-0.041 (-0.086, 0.004)
≥ 8.00 (n = 551)	0.072 (0.037, 0.108)^‡	0.060 (0.025, 0.095)^†	0.049 (0.005, 0.093)^*
Daily LPA time, hours
< 5.00 (n = 530)	-0.112 (-0.158, -0.066)^‡	-0.091 (-0.137, -0.044)^‡	-0.073 (-0.123, -0.023)^†
≥ 5.00 (n = 499)	0.027 (-0.020, 0.073)	0.033 (-0.013, 0.079)	0.038 (-0.008, 0.084)
Daily MVPA time, hours
< 2.00 (n = 902)	-0.123 (-0.183, -0.063)^‡	-0.119 (-0.179, -0.060)^‡	-0.108 (-0.175, -0.041)^†
≥ 2.00 (n = 127)	-0.067 (-0.184, 0.050)	-0.079 (-0.201, 0.042)	-0.087 (-0.210, 0.036)

^aModel 1 was adjusted for age, sex, education, wear seasons, and daily wear time of ActiGraph; Model 2 was additionally adjusted for smoking, alcohol intake, APOE ε4 allele, obesity, hypertension, dyslipidemia, diabetes, stroke, and coronary heart disease; and in Model 3, the analyses of MVPA and LPA were mutually adjusted for each other and the analyses of SB were adjusted for MVPA
Abbreviations: SB Sedentary behavior, LPA Light-intensity physical activity, MVPA Moderate-to-vigorous-intensity physical activity, NfL Neurofilament light chain
^*P < 0.05, ^†P < 0.01, ^‡P < 0.001

ISSN: 1742-4933