Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study

Wang, Yongxiang; Han, Qi; Han, Xiaolei; Dong, Yi; Mao, Ming; Wang, Chaoqun; Wang, Xiaojie; Tang, Shi; Liu, Cuicui; Li, Yuanjing; Hou, Tingting; Cong, Lin; Du, Yifeng; Qiu, Chengxuan

doi:10.1186/s12979-023-00363-7

Table 3 Associations of accelerometer-assessed movement behaviors with serum biomarkers of systemic low-grade inflammation (n = 991)

From: Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study

Behavioral factors	β-coefficient (95% confidence interval), z scores of serum cytokines
Behavioral factors	Model 1^#	Model 2^#	Model 3^#
IL-6, z-score
Daily SB time, hours	0.06 (0.03, 0.10)^‡	0.06 (0.02, 0.09)^†	0.04 (-0.01, 0.10)
Daily LPA time, hours	-0.07 (-0.12, -0.02)^†	-0.06 (-0.11, -0.01)^*	-0.04 (-0.10, 0.01)
Daily MVPA time, hours	-0.13 (-0.21, -0.05)^†	-0.10 (-0.18, -0.02)^*	-0.08 (-0.16, 0.01)
IL-8, z-score
Daily SB time, hours	0.05 (0.01, 0.09)^*	0.05 (0.01, 0.09)^*	0.05 (-0.01, 0.11)
Daily LPA time, hours	-0.06 (-0.12, -0.01)^*	-0.06 (-0.12, -0.01)^*	-0.05 (-0.11, 0.01)
Daily MVPA time, hours	-0.07 (-0.15, 0.02)	-0.08 (-0.16, -0.01)	-0.05 (-0.14, 0.04)
TNF-α, z-score
Daily SB time, hours	0.06 (0.02, 0.09)^†	0.05 (0.01, 0.08)^*	0.03 (-0.02, 0.09)
Daily LPA time, hours	-0.07 (-0.11, -0.02)^†	-0.05 (-0.10, 0.00)^*	-0.03 (-0.09, 0.02)
Daily MVPA time, hours	-0.10 (-0.18, -0.02)^*	-0.10 (-0.17, -0.02)^*	-0.08 (-0.16, 0.01)
ICAM-1, z-score
Daily SB time, hours	0.02 (-0.02, 0.06)	0.01 (-0.02, 0.05)	0.04 (-0.02, 0.10)
Daily LPA time, hours	-0.04 (-0.09, 0.01)	-0.03 (-0.08, 0.02)	-0.04 (-0.10, 0.02)
Daily MVPA time, hours	-0.01 (-0.09, 0.07)	0.01 (-0.07, 0.09)	0.04 (-0.05, 0.12)
Low-grade inflammation, composite score
Daily SB time, hours	0.05 (0.02, 0.07)^‡	0.04 (0.02, 0.07)^†	0.04 (0.01, 0.08)^*
Daily LPA time, hours	-0.06 (-0.09, -0.03)^‡	-0.05 (-0.09, -0.02)^†	-0.04 (-0.08, -0.01)^*
Daily MVPA time, hours	-0.08 (-0.13, -0.03)^†	-0.07 (-0.12, -0.01)^*	-0.04 (-0.10, 0.02)

^#Model 1 was adjusted for age, sex, education, wear seasons, and daily wear time of ActiGraph; Model 2 was additionally adjusted for smoking, alcohol intake, APOE ε4 allele, obesity, hypertension, dyslipidemia, diabetes, stroke, and coronary heart disease; and in Model 3, the analyses of MVPA and LPA were mutually adjusted for each other and the analyses of SB were adjusted for MVPA
Abbreviations: SB Sedentary behavior, LPA Light physical activity, MVPA Moderate-to-vigorous intensity physical activity, IL-6 Interleukin-6, IL-8 Interleukin-8, TNF-α Tumor necrosis factor alpha, ICAM-1 Intercellular cell adhesion molecule-1
^*P < 0.05, ^†P < 0.01, ^‡P < 0.001

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