Fig. 6

The effects of high plasma Aβ_1-42 on proportion changes of MDSCs in spleen. a The alterations of MDSCs (including PMN-MDSCs and M-MDSCs) proportions in Wt, Tg, PaWt(Wt-Wt), and PaWt(Wt-Tg) mice spleen MNCs. M-MDSCs and PMN-MDSCs were stained with Ly6C⁺Ly6G⁻ and Ly6C⁻Ly6G.⁺, respectively. b The statistical diagram of MDSCs in Wt and Tg mice spleen MNCs. At the age of 7 months, the proportions of MDSC in Tg mice spleen MNCs were significantly decreased (p = 0.000), while at the age of 11 months, the proportions of MDSCs were increased significantly (p = 0.000) when compared with Wt mice. c The statistical diagram of MDSCs in PaWt(Wt-Wt), and PaWt(Wt-Tg) mice spleen MNCs. After parabiosis for 4 months, the proportions of MDSCs in PaWt(Wt-Tg) mice spleen MNCs were significantly decreased (p = 0.001), while after parabiosis for 8 months, their proportions were significantly increased (p = 0.000) compared with PaWt(Wt-Wt) mice. d The alterations of MDSCs proportions in Wt mice injected with Aβ_1-42 and Wt mice. The proportions of MDSCs in Wt mice spleen MNCs were increased significantly after tail intravenous injection with Aβ_1-42 compared with Wt mice injected with PBS (p = 0.029). (Wt, Tg, and PaWt(Wt-Tg) mice n = 6 for each group; PaWt(Wt-Wt)mice n = 12, data from the two Wt mice of Pa(Wt-Wt) mice, Mean ± SD, one-way analysis of variance, ***P < 0.001, **P < 0.01, ns denotes no statistical significance)