Fig. 8
The effects of high plasma Aβ1-42 on the proliferation of BMCs. a The proliferations of BMCs in Wt and Tg mice at the age of 7 and 11 months. At the ages of 7 months, the proliferations of BMCs in Tg mice were increased significantly compared with Wt mice (at 2, 5 days p = 0.000, at 6 days p = 0.003, at 7 days p = 0.001), the proliferations of BMCs in Tg mice were increased significantly consistently compared with Wt mice at the ages of 11 months (at 2 days p = 0.003, at 5 days p = 0.001, at 6 and 7 days p = 0.009). b The proliferations of BMCs in PaWt(Wt-Wt) and paWt(Wt-Tg) mice at the ages of 7 and 11 months. After parabiosis for 4 months, the proliferations of BMCs in PaWt(Wt-Tg) mice were increased significantly compared with PaWt(Wt-Wt) mice (at 2 days p = 0.001, at 5 days p = 0.000, at 6 and 7 days p = 0.001), and the proliferations of BMCs in PaWt(Wt-Tg) mice were increased significantly consistently compared with PaWt(Wt-Wt) mice after parabiosis for 8 months (at 2 days p = 0.290, at 5 days p = 0.034, at 6 days p = 0.006, at 7 days p = 0.003). c The proliferations of BMCs in Wt mice injected with Aβ1-42 and the controls injected with PBS. The proliferations of BMCs in Wt mice were increased significantly after intravenous injection with Aβ1-42 (at 1 day p = 0.025, at 3 days p = 0.004, at 5 days p = 0.046, at 7 days p = 0.019, at 9 days p = 0.371, at 12 days p = 0.154, at 14 days p = 0.515) compared with those injected with PBS. d The proliferations of BMCs after co-cultured with Aβ1-42 peptide in vitro. The proliferation of BMCs showed significant increment (at 1 and 3 days p = 0.032, at 5 days p = 0.008, at 7 days p = 0.056) after co-cultured with Aβ1-42 peptide in vitro. (n = 6, Mean ± SD, one-way analysis of variance, ***P < 0.001, **P < 0.01, *P < 0.05, ns denotes no statistical significance)