Fig. 1From: Toll-like receptor 4 (TLR4): new insight immune and aging TLR4 signaling pathways: MyD88-dependent and independent downstream signaling. MyD88-dependent signaling produces pro-inflammatory cytokines through IRAK/TRAF6/TAK1 and MAPK an NF-κB activation. MyD88-independent signaling produces type I IFNs through TRIF/TRAM/TBK1 and IRF3 activationBack to article page