From: Frailty is related to serum inflammageing markers: results from the VITAL study
Median (IQR) | Unit | Total | Young | Middle- age | Older |
---|---|---|---|---|---|
N | Ā | 317 | 63 | 95 | 159 |
āGroup a | |||||
āIL-6 | pg/mL | 0.89 (0.46ā1.37) | 0.40 (0.22ā0.84) | 0.69 (0.43ā1.12) | 1.10 (0.72ā1.74) |
āElastase | ng/mL | 208 (153ā296) | 175 (128ā220) | 195 (154ā271) | 228 (166ā338) |
āsCD163 | ng/mL | 745 (518ā1134) | 529 (381ā547) | 681 (530ā1039) | 906 (627ā1244) |
āCXCL10 (IP-10) | pg/mL | 24.7 (18.8ā31.7) | 18.8 (14.7ā23.2) | 21.2 (17.5ā28.5) | 29.1 (22.1ā35.4) |
āYKL-40 | ng/mL | 37.6 (26.0ā67.7) | 24.3 (19.7ā31.2) | 30.3 (22.0ā42.9) | 58.2 (35.8ā93.6) |
āNeopterin | nmol/L | 8.47 (5.74ā11.33) | 5.78 (4.11ā8.01) | 7.65 (5.64ā9.72) | 10.45 (7.13ā13.95) |
Group b | |||||
āCCL2 | pg/mL | 402 (317ā498) | 335 (290ā416) | 413 (319ā519) | 417 (339ā523) |
āIL-8 | pg/mL | 20.5 (14.8ā34.1) | 14.9 (11.5ā21.4) | 20.5 (15.3ā42.6) | 22.3 (16.4ā35.4) |
āsIL-6R | ng/mL | 46.9 (41.3ā52.9) | 42.8 (37.3ā49.6) | 47.1 (41.3ā52.9) | 48.4 (42.4ā53.8) |
āiFABP2 | pg/mL | 1138 (843ā1644) | 908 (660ā1233) | 1113 (863ā1507) | 1235 (932ā1839) |
āsGP130 | ng/mL | 143 (131ā157) | 134 (120ā145) | 143 (130ā158) | 147 (136ā158) |
Group c | |||||
āPR3 | ng/mL | 32.4 (24.5ā46.8) | 27.9 (22.6ā38.6) | 28.7 (19.9ā42.9) | 37.9 (26.4ā52.7) |
āCRP | mg/L | 1.19 (0.55ā2.82) | 0.75 (0.23ā1.89) | 1.00 (0.45ā2.29) | 1.62 (0.68ā3.31) |
āsCD14 | ng/mL | 1446 (1252ā1645) | 1327 (1129ā1533) | 1418 (1229ā1573) | 1661 (1135ā2254) |
āAngiopoietin-2 | pg/mL | 2023 (1593ā2742) | 1787 (1268ā2545) | 1909 (1545ā2319) | 2233 (1749ā3000) |
āsCD25 | pg/mL | 522 (427ā653) | 467 (381ā547) | 478 (388ā61) | 595 (488ā718) |
āIL-1RA | pg/mL | 855 (670ā1106) | 708 (567ā975) | 770 (651ā992) | 936 (779ā1245) |
āIFN-Ī³ | pg/mL | 0.04 (0.03ā0.07) | 0.03 (0.02ā0.04) | 0.04 (0.02ā0.06) | 0.05 (0.03ā0.08) |
āSAA | ng/mL | 135 (6ā735) | 45 (5ā356) | 67 (5ā356) | 259 (39ā886) |
Group d | |||||
āCalprotectin | ng/mL | 1586 (1102ā2310) | 1538 (772ā2084) | 1661 (1135ā2254) | 1661 (1135ā2254) |
āC5a | ng/mL | 21.3 (16ā28.6) | 19.5 (15.6ā25.5) | 19.6 (14.7ā28.7) | 22.7 (16.9ā29.5) |
āPTX-3 | pg/mL | 5519 (4103ā7188) | 5328 (3789ā6988) | 5402 (4032ā6949) | 5679 (4697ā7278) |
āCathepsin G | ng/mL | 6.62 (4.70ā8.66) | 6.48 (4.60ā8.04) | 6.10 (4.65ā8.83) | 7.20 (4.83ā8.77) |
āA1AT/elastase complex | Āµg/mL | 56 (38ā96) | 55 (9ā106) | 73 (26ā135) | 52 (39ā81) |
āGM-CSF | pg/mL | 0.17 (0.13ā0.22) | 0.17 (0.13ā0.23) | 0.17 (0.12ā0.22) | 0.18 (0.13ā0.22) |
āIL-1Ī² | pg/mL | 0.03 (0.01ā0.-6) | 0.02 (0.01ā0.05) | 0.04 (0.02ā0.07) | 0.03 (0.01ā0.06) |
āTNF-Ī± | pg/mL | 2.22 (1.87ā2.68) | 2.08 (1.72ā2.52) | 2.31 (1.81ā2.68) | 2.21 (1.81ā2.68) |
āIL-10 | pg/mL | 0.57 (0.42ā0.83) | 0.50 (0.38ā0.68) | 0.66 (0.45ā0.86) | 0.56 (0.40ā0.84) |
āIFN-Ī± | pg/mL | 0.01 (0.01ā0.02) | 0.01 (0.01ā0.02) | 0.01 (0.00ā0.02) | 0.01 (0.01ā0.02) |