Fig. 2

Rag1KOThy1KO ATAμκTg mice generate mature &middle age ATA B tumor. A Summary of ATAμκTg ATA B generation and old aged ATA B tumor place. ATA B IgM react with intestinal microbiota, and higher in colon, a-IgM is the control. B and C Summary of ATAμκTg with Thy-1^KO or Rag1^KO. Thy-1^KO showed decreased B-1 ATA B cells with CD5^–, rather B-2 non-ATA B cells increase. Rag1^KO showed increased MZ B and B-1 ATA B, and both not generated CD5. D and E ZAP70 levels in ATA B-cell/lymphoma generation in TC^–, TC⁺, TC^–Rag1^KO, and TC^–Rag1^KOThy-1^KO mouse levels with negative FO B as set to 1.0. TC^–ATAμκTg Rag1^KOThy-1^KOATA B mice highest ZAP70, and generated early (mature & middle) age ATA B-cell/lymphoma generation. High CD86 and high CD24 are different with old age most TC^–ZAP70^–CD5^– ATAμκTg mice, but cyclin D2 and c-Myc are continually high as TC^–ATAμκTg mice