Fig. 5

12 mo TC^–CD5 down ATA B spleen⁺⁺ cells similar to old aged TC^–ATA B lymphoma/leukemia. TC⁺ Tg ATA B lymphoma/leukemia are NF-kB1 high. Old aged TC^– ATA B are CD11b⁺⁺CD22⁺⁺, CD24^low, and Hamp2⁺⁺ generation, and V8-12 with V_k19 AGcA MZ B are 12 mo Hamp2⁺ and old age generated macrophage⁺⁺ with intestinal tumor. A and B. 12 mo TC^–CD5^– ATA B with spleen⁺⁺ generate similar to old aged TC^–CD5^–ATA B tumor. TC⁺Tg ATA B CLL/lymphoma are higher NF-kB and TCL1 induced miR21 and miR155 and down miR29. C TC^– lymphoma/leukemia showed CD11b⁺⁺CD22⁺⁺ and generate Hamp2⁺⁺ (TC^–ZAP70^– are more IL10 and IL-6, and TC^–ZAP70⁺ are high IL-22R) with iron down, as USF2⁺, TFR⁺, FPN^–. D TC^– ATA B lymphoma/leukemia generated high Hamp2 and CD44⁺⁺CD24^low. Human V2-5 positive papers, as kidney, Breast cancer, Pancreatic cancer, SARS-CoV-2, and SLE. Breast cancer are CD44⁺⁺CD24^lo. E Some ATA B tumor showed together with high myeloid cells (CD11b⁺Gr-1⁺) [13], and V_H8-12/V_k19 AGcA generate MZ B with Hamp2⁺ in 12 mo, then old aged generate macrophages⁺⁺ in spleen with intestine/color tumor⁺⁺