Fig. 7

TC⁺Tg B1 B cells in neonate to early age are changed than TC^–. Old aged TC^–ATA B cells similar to human CLL/U-CLL and further some different. A Summary. In B-1 B cell generations, aged ability for lymphoma or CLL/lymphoma [13, 25, 178, 180], and V1-55 in C57BL/6 mice is high at 2-3 wk, than 1 wk [170]. Down: 2 mo Lin28 Tg⁺ changed are high V1-55 and decreased V1-55 with negative TdT^KO Lin28 Tg⁺ persentage, as TdT requaded for B-2 from Pro-B (TdT⁺) move to Pre-B. When V1-55 and V12-3 B-1 Pro-B to Pre-B cell stage with heavy chain with surrogate light chain (SLC) association to B-2 analysis. Thus, increased in TC⁺Tg. B 12 mo microarray relative miRNA level Let-7 showed slightly higher in TC⁺Tg ATA B cells than TC^–, and TC^– ATA B are low miR150 and miR181b. C High increased CD11b and Hamp2 in old age TC^– ATAμκTg mice. D Concludion of difference of TC⁺Tg and TC^– mice to generated lymphoma/leukemia, and in C.B17 mice TC^–ATAμκTg ATA B from neonate, middle age, and old aged. Old age ATAB lymphoma/leukemia generation with most similar to human TC⁺CLL/U–CLL and different to CLL with CD11b⁺⁺Hamp2⁺⁺, CD22⁺⁺, CD24^lo/–. CD23^–CD49d^low are the some generated cancers. AGcA generate MZ B and changed to increased macrophages⁺⁺ with intestine/colon tumor in old age