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Table 2 Discrimination performance of models

From: Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer’s disease and vascular dementia in a prospective study

  

ntotal

ncases

CAIDE Model 1a

CAIDE Model 2b

AUC (95% CI)

∆ AUC (95% CI)c

AUC (95% CI)

∆ AUC (95% CI)c

Total cohort

All-cause dementia

 CAIDE Model

1918

562

0.702 (0.669-0.732)

-

0.725 (0.695-0.755)

-

 CAIDE Model + inflam. biomarkersd

0.704 (0.670-0.738)

0.001 (-0.030-0.021)

0.724 (0.693-0.755)

-0.001 (-0.027-0.019)

Alzheimer’s disease

 CAIDE Model

1529

173

0.702 (0.649-0.747)

-

0.752 (0.704-0.798)

-

 CAIDE Model + inflam. biomarkersd

0.702 (0.646-0.755)

0.000 (-0.051-0.038)

0.749 (0.692-0.800)

-0.002 (-0.049-0.029)

Vascular dementia

 CAIDE Model

1555

199

0.700 (0.651-0.749)

-

0.707 (0.661-0.753)

-

 CAIDE Model + inflam. biomarkersd

0.698 (0.644-0.751)

-0.002 (-0.050-0.0327)

0.706 (0.656-0.755)

-0.001 (-0.047-0.039)

Mid-Life (50-64 years)

All-cause dementia

  

 CAIDE Model

1074

207

0.697 (0.652-0.743)

-

0.721 (0.673-0.769)

-

 CAIDE Model + inflam. biomarkerse

0.701 (0.646-0.748)

0.004 (-0.044-0.040)

0.718 (0.665-0.768)

-0.003 (-0.051-0.035)

Alzheimer’s disease

  

 CAIDE Model

932

65

0.700 (0.619-0.783)

-

0.751 (0.678-0.830)

-

 CAIDE Model + inflam. biomarkerse

0.690 (0.602-0.772)

-0.010 (-0.091-0.050)

0.737 (0.656-0.820)

-0.014 (-0.087-0.036)

Vascular dementia

 CAIDE Model

935

68

0.665 (0.587-0.740)

-

0.672 (0.589-0.750)

-

 CAIDE Model + inflam. biomarkerse

0.691 (0.610-0.762)

0.026 (-0.062-0.096)

0.693 (0.608-0.767)

0.021 (-0.083-0.089)

Late-life (65-75 years)

All-cause dementia

 CAIDE Model

844

355

0.582 (0.535-0.633)

-

0.624 (0.570-0.676)

-

 CAIDE Model + inflam. biomarkersf

0.576 (0.528-0.626)

-0.006 (-0.066-0.039)

0.609 (0.556-0.668)

-0.014 (-0.069-0.024)

Alzheimer’s disease

 CAIDE Model

597

108

0.575 (0.473-0.655)

-

0.651 (0.566-0.724)

-

 CAIDE Model + inflam. biomarkersf

0.595 (0.492-0.676)

0.021 (-0.087-0.109)

0.650 (0.561-0.725)

-0.001 (-0.084-0.061)

Vascular dementia

 CAIDE Model

620

131

0.558 (0.465-0.637)

-

0.582 (0.488-0.665)

-

 CAIDE Model + inflam. biomarkersf

0.547 (0.460-0.629)

-0.010 (-0.100-0.074)

0.556 (0.475-0.641)

-0.026 (-0.126-0.043)

  1. Abbreviations: inflam Inflammatory, AUC Area under the curve, CI Confidence interval
  2. aThe CAIDE model 1 includes age, education, sex, systolic blood pressure, body-mass index, total cholesterol and physical activity
  3. bThe CAIDE model 2 includes the variables of CAIDE model 1 and APOE ε4 status
  4. cThe 95% CI is the bootstrap interval for the differences in AUCs.
  5. dThe inflammatory biomarkers selected by the LASSO regression are shown in Table 3
  6. eThe inflammatory biomarkers selected by the LASSO regression for all-cause dementia, Alzheimer’s disease and vascular dementia are shown in Suppl. Tables 9, 10 and 11, respectively
  7. fThe inflammatory biomarkers selected by the LASSO regression for all-cause dementia, Alzheimer’s disease and vascular dementia are shown in Suppl. Tables 12, 13 and 14, respectively
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Immunity & Ageing

ISSN: 1742-4933

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