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  1. Research

    Acute phase of aortic dissection: a pilot study on CD40L, MPO, and MMP-1, -2, 9 and TIMP-1 circulating levels in elderly patients

    Acute aortic dissection (AAD) is an event which may be rapidly fatal without early diagnosis and treatment. Aging is one of the main risk factors that could leading to AAD. To date, no specific biomarkers are ...

    E. Vianello, E. Dozio, R. Rigolini, M. M. Marrocco-Trischitta, L. Tacchini, S. Trimarchi and M. M. Corsi Romanelli

    Immunity & Ageing 2016 13:9

    Published on: 22 March 2016

  2. Short report

    Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians

    Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians.

    Jungwon Han, So-Hyun Park, Dong-Jo Kim, Hyori Kim, Yoon-Ho Choi, Jong-Hyuk Lee, Sang Chul Park and Junho Chung

    Immunity & Ageing 2016 13:8

    Published on: 22 March 2016

  3. Research

    TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study

    To investigate mechanisms that determine healthy aging is of major interest in the modern world marked by longer life expectancies. In addition to lifestyle and environmental factors genetic factors also play ...

    Lutz Hamann, Jasmin Bustami, Leonid Iakoubov, Malgorzata Szwed, Malgorzata Mossakowska, Ralf R. Schumann and Monika Puzianowska-Kuznicka

    Immunity & Ageing 2016 13:7

    Published on: 17 March 2016

  4. Research

    Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence

    Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and probiotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via a...

    Agnieszka Przemska-Kosicka, Caroline E. Childs, Sumia Enani, Catherine Maidens, Honglin Dong, Iman Bin Dayel, Kieran Tuohy, Susan Todd, Margot A. Gosney and Parveen Yaqoob

    Immunity & Ageing 2016 13:6

    Published on: 15 March 2016

  5. Research

    Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

    Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Mea...

    Shu-Chun Chuang, Heiner Boeing, Stein Emil Vollset, Øivind Midttun, Per Magne Ueland, Bas Bueno-de-Mesquita, Martin Lajous, Guy Fagherazzi, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Tilman Küehn, Tobias Pischon, Dagmar Drogan, Anne Tjønneland, Kim Overvad, J Ramón Quirós…

    Immunity & Ageing 2016 13:5

    Published on: 25 February 2016

  6. Research

    Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration

    The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patie...

    Judith Lechner, Mei Chen, Ruth E. Hogg, Levente Toth, Giuliana Silvestri, Usha Chakravarthy and Heping Xu

    Immunity & Ageing 2016 13:4

    Published on: 16 February 2016

  7. Research

    Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy

    Homeostatic mechanisms to maintain the T cell compartment diversity indicate an ongoing process of thymic activity and peripheral T cell renewal during human life. These processes are expected to be accelerate...

    Manuela Zlamy, Giovanni Almanzar, Walther Parson, Christian Schmidt, Johannes Leierer, Birgit Weinberger, Verena Jeller, Karin Unsinn, Matthias Eyrich, Reinhard Würzner and Martina Prelog

    Immunity & Ageing 2016 13:3

    Published on: 2 February 2016

  8. Research

    Pneumococcal colonization in older adults

    Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the wi...

    Susanna Esposito, Daniela Mari, Luigi Bergamaschini, Annalisa Orenti, Leonardo Terranova, Luca Ruggiero, Valentina Ierardi, Monia Gambino, Francesco Della Croce and Nicola Principi

    Immunity & Ageing 2016 13:2

    Published on: 12 January 2016

  9. Research

    Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years

    Cytomegalovirus (CMV) is a highly prevalent herpesvirus, which maintains lifelong latency and places a significant burden on host immunity. Infection is associated with increased rates of vascular disease and ...

    Helen M. Parry, Jianmin Zuo, Guido Frumento, Nikhil Mirajkar, Charlotte Inman, Emma Edwards, Mike Griffiths, Guy Pratt and Paul Moss

    Immunity & Ageing 2016 13:1

    Published on: 5 January 2016

  10. Research

    Serum BPIFB4 levels classify health status in long-living individuals

    People that reach extreme ages (Long-Living Individuals, LLIs) are object of intense investigation for increase/decrease of genetic variant frequencies, genetic methylation levels, protein abundance in serum a...

    Francesco Villa, Alberto Malovini, Albino Carrizzo, Chiara C. Spinelli, Anna Ferrario, Anna Maciąg, Michele Madonna, Riccardo Bellazzi, Luciano Milanesi, Carmine Vecchione and Annibale A. Puca

    Immunity & Ageing 2015 12:27

    Published on: 15 December 2015

  11. Research

    End stage renal disease patients have a skewed T cell receptor Vβ repertoire

    End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens....

    Ling Huang, Anton W. Langerak, Ingrid L. M. Wolvers-Tettero, Ruud W. J. Meijers, Carla C. Baan, Nicolle H. R. Litjens and Michiel G. H. Betjes

    Immunity & Ageing 2015 12:28

    Published on: 14 December 2015

  12. Research

    Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II

    Aging and latent infection with Cytomegalovirus (CMV) are thought to be major factors driving the immune system towards immunosenescence, primarily characterized by reduced amounts of naïve T-cells and increas...

    Kilian Wistuba-Hamprecht, Karin Haehnel, Nicole Janssen, Ilja Demuth and Graham Pawelec

    Immunity & Ageing 2015 12:25

    Published on: 4 December 2015

  13. Research

    Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study

    Bacillus probiotics health benefits have been until now quite poorly studied in the elderly population. This study aimed to assess the effects of Bacillus subtilis CU1 consumption on i...

    Marie Lefevre, Silvia M. Racedo, Gabrielle Ripert, Béatrice Housez, Murielle Cazaubiel, Corinne Maudet, Peter Jüsten, Philippe Marteau and Maria C. Urdaci

    Immunity & Ageing 2015 12:24

    Published on: 3 December 2015

  14. Short report

    Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies

    Degenerative granular structures appear progressively with age in the hippocampus of most mouse strains. We recently reported that these granules contain a neo-epitope that is recognised by IgM antibodies pres...

    Gemma Manich, Elisabet Augé, Itsaso Cabezón, Mercè Pallàs, Jordi Vilaplana and Carme Pelegrí

    Immunity & Ageing 2015 12:23

    Published on: 24 November 2015

  15. Research

    IL7R gene expression network associates with human healthy ageing

    The level of expression of the interleukin 7 receptor (IL7R) gene in blood has recently been found to be associated with familial longevity and healthy ageing. IL7R is crucial for T cell development and important...

    Willemijn M. Passtoors, Erik B. van den Akker, Joris Deelen, Andrea B. Maier, Ruud van der Breggen, Rick Jansen, Stella Trompet, Diana van Heemst, Evelyna Derhovanessian, Graham Pawelec, Gert-Jan B. van Ommen, P. Eline Slagboom and Marian Beekman

    Immunity & Ageing 2015 12:21

    Published on: 11 November 2015

  16. Review

    Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

    Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneratio...

    Sandro Dattilo, Cesare Mancuso, Guido Koverech, Paola Di Mauro, Maria Laura Ontario, Cateno Concetto Petralia, Antonino Petralia, Luigi Maiolino, Agostino Serra, Edward J. Calabrese and Vittorio Calabrese

    Immunity & Ageing 2015 12:20

    Published on: 4 November 2015

  17. Research

    NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study

    The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms have been associated with autoinflammatory d...

    Tarja Kunnas, Kirsi Määttä and Seppo T. Nikkari

    Immunity & Ageing 2015 12:19

    Published on: 31 October 2015

  18. Research

    Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation

    Thymic involution is thought to be an important factor of age related immunodeficiency. Understanding the molecular mechanisms of human thymic senescence may lead to the discovery of novel therapeutic approach...

    Maria Danielma dos Santos Reis, Krisztian Csomos, Luciene Paschoal Braga Dias, Zsolt Prodan, Tamas Szerafin, Wilson Savino and Laszlo Takacs

    Immunity & Ageing 2015 12:18

    Published on: 29 October 2015

  19. Short report

    Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age

    Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-i...

    Xiaoyu Wu, Maani Hakimi, Markus Wortmann, Jian Zhang, Dittmar Böckler and Susanne Dihlmann

    Immunity & Ageing 2015 12:15

    Published on: 6 October 2015

  20. Research

    Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4+ T cells in aged rats

    Aging influences immune response and susceptibility to EAE in a strain specific manner. The study was designed to examine influence of aging on EAE induction in Albino Oxford (AO) rats.

    Zorica Stojić-Vukanić, Mirjana Nacka-Aleksić, Ivan Pilipović, Ivana Vujnović, Veljko Blagojević, Duško Kosec, Mirjana Dimitrijević and Gordana Leposavić

    Immunity & Ageing 2015 12:16

    Published on: 6 October 2015

  21. Research

    The immunological footprint of CMV in HIV-1 patients stable on long-term ART

    Most HIV-infected persons are cytomegalovirus (CMV) seropositive and retain latent virus that can be reactivated by immune activation. Their T cell populations express markers reflecting a late stage of differ...

    Jacquita S. Affandi, Jacinta Montgomery, Samantha J. Brunt, David Nolan and Patricia Price

    Immunity & Ageing 2015 12:14

    Published on: 1 October 2015

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