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  1. Research

    Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes

    Over the past fifteen years, we have demonstrated that cortisol and dehydroepiandrosterone (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system....

    Emanuela Corsini, Valentina Galbiati, Angela Papale, Elena Kummer, Antonella Pinto, Melania M. Serafini, Antonio Guaita, Roberto Spezzano, Donatella Caruso, Marina Marinovich and Marco Racchi

    Immunity & Ageing 2016 13:20

    Published on: 29 May 2016

  2. Editorial

    Nutrigerontology: a key for achieving successful ageing and longevity

    During the last two centuries the average lifespan has increased at a rate of approximately 3 months/year in both sexes, hence oldest old people are becoming the population with the fastest growth in Western W...

    Anna Aiello, Giulia Accardi, Giuseppina Candore, Giuseppe Carruba, Sergio Davinelli, Giuseppe Passarino, Giovanni Scapagnini, Sonya Vasto and Calogero Caruso

    Immunity & Ageing 2016 13:17

    Published on: 21 May 2016

  3. Research

    Effects of thermal water inhalation in chronic upper respiratory tract infections in elderly and young patients

    Chronic upper respiratory tract infections (cURTI) are very frequent illnesses which occur at any age of life. In elderly, cURTI are complicated by immunosenescence, with involvement of lung immune responsiven...

    Thea Magrone, Mauro Galantino, Nunzio Di Bitonto, Luisella Borraccino, Gerardo Chiaromonte and Emilio Jirillo

    Immunity & Ageing 2016 13:18

    Published on: 5 May 2016

  4. Review

    Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

    An extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of pla...

    Sergio Davinelli, Michael Maes, Graziamaria Corbi, Armando Zarrelli, Donald Craig Willcox and Giovanni Scapagnini

    Immunity & Ageing 2016 13:16

    Published on: 14 April 2016

  5. Research

    β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake

    It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not...

    Annalisa Barera, Silvio Buscemi, Roberto Monastero, Calogero Caruso, Rosalia Caldarella, Marcello Ciaccio and Sonya Vasto

    Immunity & Ageing 2016 13:14

    Published on: 7 April 2016

  6. Review

    Nutrition, aging and cancer: lessons from dietary intervention studies

    There is convincing epidemiological and clinical evidence that, independent of aging, lifestyle and, notably, nutrition are associated with development or progression of major human cancers, including breast, ...

    Giuseppe Carruba, Letizia Cocciadiferro, Antonietta Di Cristina, Orazia M. Granata, Cecilia Dolcemascolo, Ildegarda Campisi, Maurizio Zarcone, Maria Cinquegrani and Adele Traina

    Immunity & Ageing 2016 13:13

    Published on: 7 April 2016

  7. Review

    Human longevity: Genetics or Lifestyle? It takes two to tango

    Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic ...

    Giuseppe Passarino, Francesco De Rango and Alberto Montesanto

    Immunity & Ageing 2016 13:12

    Published on: 5 April 2016

  8. Research

    Nutraceutical effects of table green olives: a pilot study with Nocellara del Belice olives

    The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin o...

    Giulia Accardi, Anna Aiello, Valeria Gargano, Caterina Maria Gambino, Santo Caracappa, Sandra Marineo, Gesualdo Vesco, Ciriaco Carru, Angelo Zinellu, Maurizio Zarcone, Calogero Caruso and Giuseppina Candore

    Immunity & Ageing 2016 13:11

    Published on: 5 April 2016

  9. Research

    Acute phase of aortic dissection: a pilot study on CD40L, MPO, and MMP-1, -2, 9 and TIMP-1 circulating levels in elderly patients

    Acute aortic dissection (AAD) is an event which may be rapidly fatal without early diagnosis and treatment. Aging is one of the main risk factors that could leading to AAD. To date, no specific biomarkers are ...

    E. Vianello, E. Dozio, R. Rigolini, M. M. Marrocco-Trischitta, L. Tacchini, S. Trimarchi and M. M. Corsi Romanelli

    Immunity & Ageing 2016 13:9

    Published on: 22 March 2016

  10. Short report

    Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians

    Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians.

    Jungwon Han, So-Hyun Park, Dong-Jo Kim, Hyori Kim, Yoon-Ho Choi, Jong-Hyuk Lee, Sang Chul Park and Junho Chung

    Immunity & Ageing 2016 13:8

    Published on: 22 March 2016

  11. Research

    TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study

    To investigate mechanisms that determine healthy aging is of major interest in the modern world marked by longer life expectancies. In addition to lifestyle and environmental factors genetic factors also play ...

    Lutz Hamann, Jasmin Bustami, Leonid Iakoubov, Malgorzata Szwed, Malgorzata Mossakowska, Ralf R. Schumann and Monika Puzianowska-Kuznicka

    Immunity & Ageing 2016 13:7

    Published on: 17 March 2016

  12. Research

    Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence

    Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and probiotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via a...

    Agnieszka Przemska-Kosicka, Caroline E. Childs, Sumia Enani, Catherine Maidens, Honglin Dong, Iman Bin Dayel, Kieran Tuohy, Susan Todd, Margot A. Gosney and Parveen Yaqoob

    Immunity & Ageing 2016 13:6

    Published on: 15 March 2016

  13. Research

    Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study

    Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Mea...

    Shu-Chun Chuang, Heiner Boeing, Stein Emil Vollset, Øivind Midttun, Per Magne Ueland, Bas Bueno-de-Mesquita, Martin Lajous, Guy Fagherazzi, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Tilman Küehn, Tobias Pischon, Dagmar Drogan, Anne Tjønneland, Kim Overvad, J Ramón Quirós…

    Immunity & Ageing 2016 13:5

    Published on: 25 February 2016

  14. Research

    Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration

    The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patie...

    Judith Lechner, Mei Chen, Ruth E. Hogg, Levente Toth, Giuliana Silvestri, Usha Chakravarthy and Heping Xu

    Immunity & Ageing 2016 13:4

    Published on: 16 February 2016

  15. Research

    Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy

    Homeostatic mechanisms to maintain the T cell compartment diversity indicate an ongoing process of thymic activity and peripheral T cell renewal during human life. These processes are expected to be accelerate...

    Manuela Zlamy, Giovanni Almanzar, Walther Parson, Christian Schmidt, Johannes Leierer, Birgit Weinberger, Verena Jeller, Karin Unsinn, Matthias Eyrich, Reinhard Würzner and Martina Prelog

    Immunity & Ageing 2016 13:3

    Published on: 2 February 2016

  16. Research

    Pneumococcal colonization in older adults

    Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the wi...

    Susanna Esposito, Daniela Mari, Luigi Bergamaschini, Annalisa Orenti, Leonardo Terranova, Luca Ruggiero, Valentina Ierardi, Monia Gambino, Francesco Della Croce and Nicola Principi

    Immunity & Ageing 2016 13:2

    Published on: 12 January 2016

  17. Research

    Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years

    Cytomegalovirus (CMV) is a highly prevalent herpesvirus, which maintains lifelong latency and places a significant burden on host immunity. Infection is associated with increased rates of vascular disease and ...

    Helen M. Parry, Jianmin Zuo, Guido Frumento, Nikhil Mirajkar, Charlotte Inman, Emma Edwards, Mike Griffiths, Guy Pratt and Paul Moss

    Immunity & Ageing 2016 13:1

    Published on: 5 January 2016

  18. Research

    Serum BPIFB4 levels classify health status in long-living individuals

    People that reach extreme ages (Long-Living Individuals, LLIs) are object of intense investigation for increase/decrease of genetic variant frequencies, genetic methylation levels, protein abundance in serum a...

    Francesco Villa, Alberto Malovini, Albino Carrizzo, Chiara C. Spinelli, Anna Ferrario, Anna Maciąg, Michele Madonna, Riccardo Bellazzi, Luciano Milanesi, Carmine Vecchione and Annibale A. Puca

    Immunity & Ageing 2015 12:27

    Published on: 15 December 2015

  19. Research

    End stage renal disease patients have a skewed T cell receptor Vβ repertoire

    End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens....

    Ling Huang, Anton W. Langerak, Ingrid L. M. Wolvers-Tettero, Ruud W. J. Meijers, Carla C. Baan, Nicolle H. R. Litjens and Michiel G. H. Betjes

    Immunity & Ageing 2015 12:28

    Published on: 14 December 2015

  20. Research

    Peripheral blood T-cell signatures from high-resolution immune phenotyping of γδ and αβ T-cells in younger and older subjects in the Berlin Aging Study II

    Aging and latent infection with Cytomegalovirus (CMV) are thought to be major factors driving the immune system towards immunosenescence, primarily characterized by reduced amounts of naïve T-cells and increas...

    Kilian Wistuba-Hamprecht, Karin Haehnel, Nicole Janssen, Ilja Demuth and Graham Pawelec

    Immunity & Ageing 2015 12:25

    Published on: 4 December 2015

  21. Research

    Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study

    Bacillus probiotics health benefits have been until now quite poorly studied in the elderly population. This study aimed to assess the effects of Bacillus subtilis CU1 consumption on i...

    Marie Lefevre, Silvia M. Racedo, Gabrielle Ripert, Béatrice Housez, Murielle Cazaubiel, Corinne Maudet, Peter Jüsten, Philippe Marteau and Maria C. Urdaci

    Immunity & Ageing 2015 12:24

    Published on: 3 December 2015

  22. Short report

    Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies

    Degenerative granular structures appear progressively with age in the hippocampus of most mouse strains. We recently reported that these granules contain a neo-epitope that is recognised by IgM antibodies pres...

    Gemma Manich, Elisabet Augé, Itsaso Cabezón, Mercè Pallàs, Jordi Vilaplana and Carme Pelegrí

    Immunity & Ageing 2015 12:23

    Published on: 24 November 2015

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