Figure 1
From: NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
Ageing process results by the lost of molecular fidelity followed by an improved entropy. This determines loss complexity and random accumulation of damages (i.e. particularly damages to nuclear and mitochondrial DNA) at cellular, tissue, organ levels and/or of whole body. Thus, it becomes more easily vulnerable to internal and external stressors, frailty, disability and disease.