Reactivation of immune responses against Mycobacterium tuberculosis by boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium bovis BCG

Table 1 Transition of memory T cells in BCG immunized mice with aging and retrieval effect of the boosting with Oligo-B on memory T cells ^$

^$Splenocytes were prepared from the aged mice indicated in the table and stained with specific antibodies to memory T cells (CD44, CD62L), and then analyzed by a flow cytometer. Precise procedures were described in the Section of Materials and methods.
^*The age in human equivalent was applied to survival curve of mice.
^&Mice were administered transdermally with BCG at 4-week old.
^**Effector memory T cell (T_EM), CD44^hi CD62L^lo; central memory T cell (T_CM), CD44^hi CD62L^hi.
N.D.: not determined.

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