Figure 2

Significantly decreased amounts of both μ- (A,D) and m-calpain (B,E) in the CD4⁺(A,B) and CD8⁺(D,E) as well as of calpastatin (only in the CD8⁺; C,F) lymphocytes of old people regardless the expression or lack of CD28. Significantly higher amounts of both calpains in the CD4⁺CD28^- vs. CD4⁺CD28⁺ of old people (A,B) but not in CD8⁺CD28^- vs. CD8⁺CD28⁺ (D, E) lymphocytes of young as well as old subjects. Results are shown as bars for means (CD28⁺ (□) and CD28^- (■) cells respectively) and whiskers for +/- SD. Statistical significance is indicated by asterisks at p<0.05(*) or p<0.001 (**). See Methods for the details.