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Table 2 Effect of Leptin on the expression of activation markers on B cell subsets (MFI)

From: Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans

Marker

Young

Aged

  

CD19

CD5+

CD5-

CD19

CD5+

CD5-

CD25

Control

3.6 ± .4

5.6 ± 2

5.6 ± 2

10 ± 4

7 ± 1.25

10 ± 7

Activated

9.6 ± 1.7

9.5 ± 1.4

9.5 ± 1.4

26 ± 2

15 ± 2.5

51 ± 4.6

CD69

Control

4.5 ± 2

8.8 ± 5

4.1 ± 1.6

4.5 ± .4

7 ± 3.5

3.6 ± 8

Activated

7.6 ± 2.6

11 ± 5.9

7.3 ± 1.7

8.6 ± .47

20 ± 5.7

8 ± .8

  1. P value:
  2. CD25, Aging vs. Young: CD19 = P < 0.01, CD5 + = P < 0.001, CD5- = P < 0.045.
  3. CD69, Aging vs. Young: CD19 = ns, CD5+ = P < 0.02, CD5- = ns.