Table 1 Frequencies for pathogens and the associations between the different pathogens, cardiovascular disease (CVD), diabetes mellitus (DM) and frailty

HSV ^a IgG positive

30-2000

437 (389–484)

275 (93%)

57 (97%)

133 (93%)

122 (93%)

HSV ^a IgG negative

-

20 (7%)

2 (3%)

10 (7%)

9 (7%)

VZV ^a IgG positive

100-2000

994 (612–1403)

292 (99%)

59 (100%)

141 (99%)

128 (98%)

VZV ^a IgG negative

-

3 (1%)

0 (0%)

2 (1%)

3 (2%)

EBV ^a IgG positive

11-200

200 (130–200)

291 (99)%

58 (98%)

141 (99%)

128 (98%)

EBV ^a IgG negative

-

4 (1%)

1 (2%)

2 (1%)

3 (2%)

CMV ^a IgG positive

226 (77%)

46 (78%)

115 (80%)

108 (82%)^b

• AxSYM

15-250

250 (192–250)

• DSX^TM

40-2000

373 (290–463)

CMV ^a IgG negative

-

69 (23%)

13 (22%)

28 (20%)

23 (18%)^b

HHV6 ^a IgG positive

>1.1

1.67 (1.37-2.34)

193 (65%)

45 (76%)^c

97 (68%)

90 (69%)

HHV6 ^a IgG negative

-

102 (35%)

14 (24%)^c

46 (32%)

41 (31%)

CP ^a IgG positive

45-270

81 (59–116)

150 (51%)

28 (47%)

74 (52%)

68 (52%)

CP ^a IgG negative

-

144 (49%)

31 (53%)

69 (48%)

63 (48%)

HP ^a IgG positive

20-650

97 (36–211)

173 (59%)

32 (54%)

82 (47%)

77 (59%)

HP ^a IgG negative

-

121 (41%)

27 (46%)

61 (43%)

54 (41%)

Pathogen burden ^d

-

● Pathogen burden ≤ 4

53 (18%)

9 (15%)

25 (18%)

18 (14%)

● Pathogen burden = 5

-

95 (32%)

18 (31%)

46 (32%)

44 (33%)

● Pathogen burden = 6

-

103 (35%)

23 (39%)

46 (32%)

48 (37%)

● Pathogen burden = 7

-

44 (15%)

9 (15%)

26 (18%)

21 (16%)