Table 3 Pro- and anti-inflammatory cytokines categorised by KIR A and B haplogroups for Octo/Nonagenarians from the Belfast Elderly Longitudinal Free-Living Ageing STudy (BELFAST) with comparisons by Mann–Whitney U and Fold difference between KIR A and B cytokine levels

sIL-2R

640 [500–770](3)

865 [540–1600](16)

0.09ω

1.35

IFN-γ

1.5 [1.1–3.9](6)

1.8 [0.7–14.4](14)

0.51ω

1.2

TNF-a

25 [16–43](12)

26 [8–56](34)

0.96ω

1.0

sIL-6R

47.6 [24–55](5)

52.8 [25–104](16)

0.26ω

1.11

IL-6

6 [5–40](12)

9 [1–36](34)

0.69ω

1.5

IL-10

1.0 [0–6.5](5)

2.0 [0–4](16)

0.28ω

2.0

IL-12

97 [69–122](6)

285 [89–539](14)

0.003*ω

2.9

IL-12p70

8.2 [4–13](6)

5.4 [3–87](14)

0.17ω

0.65

IL-12p40

104[16-160](6)

280[13-430](14)

0.002* ω

2.7

12p40/p70

10.2 [6.2–22.5](6)

49.4 [5–79](14)

0.01*ω

4.8

TGF-β

33.7 [0–50](10)

32.5 [17.3–52](34)

0.52 ω

0.96

1/logTGF-β

0.83 [0.6–1.0](10)

0.70 [0.33–0.94](34)

0.02*ω

0.84

TGF-β(active)

15.6 [0–50](10)

26.9 [11–1000](33)

0.009*ω

1.7