Table 1 VEGF, IL-10 and TNF-α genotype and allele frequency in patients with chronic periodontitis and CTR
From: Variations in inflammatory genes are associated with periodontitis
VEGF | CC | CA | AA | C carriers | A carriers |
|---|---|---|---|---|---|
(n) % | (n) % | (n) % | (n) % | (n) % | |
Periodontitis (n = 77) | (56) 72.7 | (17) 22.1 | (4) 5.2 | (73) 94.8 | (21) 27.3 |
CTR (n = 214) | (72) 33.6 | (109) 50.9 | (33) 15.4 | (181) 84.6 | (142) 66.4 |
Periodontitis vs CTR χ2 = 35.210 p = 0.0001; | |||||
CC carriers vs non-CC carriers: χ2 = 35.104, p = 0.0001, OR = 5.259, ci = 2.956-9.357; | |||||
AA carriers vs non-AA carriers: χ2 = 5.335, p = 0.021, OR = 0.301, ci = 0.103-0.879; | |||||
C carriers χ2 = 5.335, p = 0.021; OR = 3.327; ci = 1.138-9.726; | |||||
A carriers χ2 = 35.104, p = 0.0001; OR = 0.190, ci = 0.107-0.338. | |||||
IL-10 | GG | GA | AA | G carriers | A carriers |
(n) % | (n) % | (n) % | (n) % | (n) % | |
Periodontitis (n = 75) | (7) 9.3 | (29) 38.7 | (39) 52 | (36) 48 | (68) 90.7 |
CTR (n = 470) | (93) 19.8 | (209) 44.5 | (168) 35.7 | (302) 64.3 | (378) 80.4 |
Periodontitis vs CTR χ2 = 8.850, p = 0.012; | |||||
GG carriers vs non-GG carriers: χ2 = 4.870, p = 0.027, OR = 0.412, ci = 0.183-0.926; | |||||
AA carriers vs non-AA carriers: χ2 = 7.054, p = 0.008, OR = 1.929, ci = 1.181-3.151; | |||||
A carriers χ2 = 4.563, p = 0.033; OR = 2.364, ci = 1.051-5.318; | |||||
G carriers χ2 = 7.255, p = 0.007; OR = 0.513, ci = 0.314-0.839. | |||||
TNF-α | GG | GA | AA | G carriers | A carriers |
(n) % | (n) % | (n) % | (n) % | (n) % | |
Periodontitis (n = 75) | (68) 90.7 | (7) 9.3 | (0) 0 | (75) 100 | (7) 9.3 |
CTR (n = 440) | (349) 79.3 | (87) 19.8 | (4) 0.9 | (436) 99.1 | (91) 20.7 |
Periodontitis vs CTR χ2 = 5.527, p = 0.063. | |||||
GG carriers vs non-GG carriers: χ2 = 5.014, p = 0.025; OR = 2.463, ci = 1.094-5.548; | |||||
AA vs non-AA carriers: χ2 = 0.861, p = 0.650. | |||||
A carriers χ2 = 5.356, p = 0.021, OR = 0.395, ci = 0.175-0.889. | |||||
G carriers χ2 = 0.687, p = 0.407. | |||||