Comparison of cytokine/chemokine plasma concentrations of aged donors with different TLR1 genotypes. Analyses were performed as described in Methods. The plasma cytokine concentrations were compared between a homozygous TLR1neg genotype group (743AA/1805GG), a heterozygous TLR1pos genotype group (743AG/1805GT), a homozygous TLR1pos genotype group (743GG/1805TT), and all TLR1 positives (743AG/1805GT and 743GG/1805TT), statistically compiled from old individuals from Germany and Italy and from nonagenarians (Italy). 743AA/1805GG genotype, n = 66–76; 743AG/1805GT genotype, n = 65-66; 743GG/1805TT genotype, n = 23; 743AG/1805GT and 743GG/1805TT genotypes, n = 88-89. Wilcoxon statistic test, mean + standard error, *p <0.05; **p < 0.01.