N | Variant allele (%) | P-value | Genotype (%) | Odds ratio (95% CI) | |||
---|---|---|---|---|---|---|---|
Pro/pro | Pro/ser | Ser/ser | |||||
P-value | |||||||
ser | C/C | C/T | T/T | ||||
Study group | |||||||
Controls 1 | 300 | 278 (46.3) | 0.008 | 87 (29.0) | 148 (49.3) | 65 (21.7) | 0.64 |
Patients | 207 | 157 (37.9) | 81 (39.1) | 95 (45.9) | 31 (15.0) | 0.38-1.02 | |
0.06 | |||||||
Confirmatory group | |||||||
Controls 2 | 305 | 268 (43.9) | 0.23 | 97 (31.8) | 148 (48.5) | 60 (19.7) | 0.76 |
Patients | 306 | 248 (40.5) | 106 (34.6) | 152 (49.7) | 48 (15.7) | 0.50-1.15 | |
0.20 | |||||||
Combined | |||||||
Controls | 605 | 546 (45.1) | 0.007 | 184 (30.4) | 296 (48.9) | 125 (20.7) | 0.69 |
Patients | 513 | 405 (39.5) | 187 (36.5) | 247 (48.1) | 79 (15.4) | 0.513-0.953 | |
0.02 |