Figure 1
From: Age matters: Young T lymphocytes offer better protection from myeloma proliferation
Growth of 5T33-MMM cells was measured by the presence of 5T33-specific IgG2b mIg in serum. Ten million HBSS-washed cultured 5T33 MMM cells were injected into 4 groups of mice on day 0: Group 1 included 18 young (2-3-month old), wild-type, C57BL/6 mice; Group 2 included 10 young (2–3 month-old) B-cell-deficient IgH-/- (B6.129S2-Igh-6tm1Cgn/J) C57BL/6 mice; Group 3 included 34 aged (18–20 month old) wild-type C57BL/6 mice; and Group 4 included 28 young (2-3-month-old) Rag1-deficient C57BL/6 B-cell and T-cell deficient mice (B6.127S7-Rag1tm1Mom/J). The difference in percentages between mice with mIg in young RAG-1 deficient and old wild-type C57BL/6 mice and between old wild-type C57BL/6 and B-cell deficient or young wild-type C57BL/6 mice were statistically different (Kaplan-Meier statistic, p < 0.021).