Figure 4
From: Age matters: Young T lymphocytes offer better protection from myeloma proliferation
Inhibition of the growth of 10 million 5T33L MMM cells injected into 6 C57BL/6 Rag1-deficient mice by 3 million HBSS-washed splenic T cells from 3 month old C57BL/6 mice 1 week earlier ( ___) or in two experiments including a total of 6 C57BL/6 Rag1-deficient mice given no purified splenic T cells from wild-type C57BL/6 mice had progressive tumor cell growth (….). One week later all C57BL/6 Rag1-deficient mice were given 10 million 5T33L MMM cells. Photon flux was measured in all 12 mice 20 minutes after luciferin and 2, 11, 18, 28, 35, and 43 days after the injection of 5T33L MMM cells. Photon flux from C57BL/6 Rag1-deficient mice given splenic T cells was significantly less than photon flux from mice given only HBSS and this difference increased progressively between 18 and 43 days after injection of the 5T33L cells (Chi-square-Fisher exact test p < 0.0025).