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Table 1 Differentially methylated sites in young versus old monocyte cell populations

From: CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing

Target ID

β-difference*

Adjusted p-value

Gene

cg10501210

−0.38

0.002884

miR-29b-2 * *

cg24892069

−0.30

0.00312

NRP1

cg27209729

−0.30

0.020571

NRXN2

cg11807280

−0.27

0.013523

 

cg08128734

−0.27

0.015965

RASSF5

cg11693709

−0.26

0.024853

PAK6

cg18826637

−0.25

0.022927

 

cg00329615

−0.25

0.012874

IGSF11

cg00740914

−0.25

0.008061

 

cg03873281

−0.25

0.005647

PDLIM4

cg13039251

−0.23

0.008793

PDZD2

cg07583137

−0.23

0.007904

CHMP4C

cg12317815

−0.22

0.014773

ASPA

cg06781608

−0.22

0.030063

PTPRN2

cg13001142

−0.22

0.011913

STXBP5

cg16932827

−0.21

0.015062

 

cg19344626

−0.21

0.010547

NWD1

cg14295611

−0.21

0.04857

 

cg14614643

−0.21

0.008462

 

cg03915012

−0.21

0.026415

GAK

cg03473532

−0.20

0.035003

MKLN1

cg02978201

0.47

0.015062

PRM1

cg04875128

0.30

0.017558

OTUD7A

cg21184711

0.23

0.024671

CADPS2

cg20665157

0.22

0.008629

CADPS2

cg19907915

0.21

0.014934

IGSF9B

  1. The three replicated CpG loci are shown in bold.
  2. *A negative β-difference indicates to hypomethylation in the elderly and a positive β-difference indicates to hypermethylation in the elderly population. Only CpG sites with FDR-adjusted p-values less than 0.05 were considered differentially methylated.
  3. **Approximately 1 kb upstream.