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Figure 1 | Immunity & Ageing

Figure 1

From: Characterization of recovery, repair, and inflammatory processes following contusion spinal cord injury in old female rats: is age a limitation?

Figure 1

Aged rats showed greater locomotor deficits. (A) Repeated-measures ANOVA yielded a main significant effect for performance of young vs aged animals (F = 2.36, *p = 0.044) in the open-field. Post-hoc tests revealed a significant difference between age groups at 7, 21 and 28 days post-injury (Bonferroni’s multiple comparison, #p<0.05). On day 28, aged rats showed greater locomotor deficits compared to the young. (B) Using CatWalk analysis, no differences in crossing time were found between age groups at baseline, but post-SCI, aged animals demonstrated an increase in this parameter compared to young. (C) Young animals exhibited decreased contact area compared to aged animals post-injury as well as relative to their pre-injury baseline. (D-E) Since base of support was significantly different between age groups at baseline (D), post-injury data were normalized to pre-injury performance (dashed line in E) and demonstrated a significant increase in base of support of aged animals compared to young (E). Student’s t-test were used to compare between groups: ***p< 0.001; **p< 0.01, *p<0.05. Mean ± SEM is shown.

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