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Figure 6 | Immunity & Ageing

Figure 6

From: Characterization of recovery, repair, and inflammatory processes following contusion spinal cord injury in old female rats: is age a limitation?

Figure 6

Aged rats showed an acute and localized increase in microglia/macrophage infiltration. Representative photomicrographs of coronal spinal cord sections immunolabeled for neutophils with CD43 (A-B) or microglia/macrophages with ED-1 (D-E) and counter-stained with methyl green are shown. Insets are of individual fields at higher magnification. Unbiased stereological quantification of total numbers of CD43-positive cells (C) and ED-1 positive cells (F) revealed no significant differences between age groups. Rostro-caudal distribution of CD43+ cells did not exhibit differences between groups (p > 0.05) (G). In contrast, ED-1 positive cells showed significantly increased age-associated microglia/macrophage response at the injury epicenter (H). Student's t-tests, *p< 0.05. Mean ± SEM is shown. Scale bar = 25 μm.

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Immunity & Ageing

ISSN: 1742-4933

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