Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians

Immunity & Ageing

Table 1 Upstream regulators associated with the level of anti-CMV IgG titre

Upstream regulator	Predicted activation state	Activation z-score	Target molecules in dataset
CD24	Activated	2.449	ADD3,EDEM3,MBNL1,SMC4,SPG11,SYNE2
Mek	Activated	2.446	ABCE1,DUSP6,LYAR,MOB4,NOP58,OSBPL8
IFNL1	Activated	2.000	GBP1,SAMD9,STAT1,TDRD7
AR	Activated	2.000	ACTR3,CAST,CTSO,STAT1,WIPF1

Upstream regulators in nonagenarians that are predicted to be associated with the anti-CMV IgG titre are listed. An activation z-score >2 or < -2 is considered significant. Target molecules are the molecules in our data set on whose expression the prediction about the upstream regulator is based.

ISSN: 1742-4933