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Figure 4 | Immunity & Ageing

Figure 4

From: Ageing gender-specific "Biomarkers of Homeostasis", to protect ourselves against the diseases of the old age

Figure 4

It is in the physio-pathological pathways that lead to chronic inflammation that it is to be researched the scientific ratio for the definition of clinical biomarkers of homeostasis for the prevention and the treatment of chronic-degenerative diseases. The procedure consists in the individuation of biologic molecules, whose variations could quantify the risk of losing the physiologic system homeostatic capacity in the control of the inflammation. These molecules have to be measurable in a practical and no-invasive way, in all the following stages: a) in the normal state of health, in which we identify biomarkers of a type that are in this case indices of no-risk of disease; b) in the transient inflammatory state, where we define biomarkers of b type that are indices of low-risk of pathology; c) in the chronic inflammatory state, in which it is possible to select biomarkers of c type that are indices of high-risk of disease. The scientific rational is that prognostic biomarkers have to be predictive for the following passages to be efficient in the prevention of chronic-degenerative diseases: 1) from the health physiologic condition (typical for the a type biomarkers), in which there is a homeostatic balance in the inflammation control, 2) to the transient inflammation (b type) where the restoration of this balance is still very probable, 3) and/or to the chronic inflammation (c type) in which this recovery is physiologically very improbable, while it is high the risk of progression toward degenerative pathologies.

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