The identification of molecules that have the function of homeostatic biomarkers. The study of the relationships between ageing and a healthy longevity, in the healthy population comparing the age subgroups, could be useful in the definition of 1) a type biomarkers (prognostic for the homeostatic state and of no-risk of pathology) and 2) b type biomarkers (prognostic for the transient inflammatory state, then of the restoration possibility of the homeostatic condition and of low-risk of pathology). These biomarkers are usable in prevention intervention on the healthy population and in the evaluation of the risk/benefit for the therapeutic selection of patients. On patients with chronic-degenerative pathologies the procedure is to select the biologic molecules with homeostatic biomarker capacity in association with the losing of the inflammation control, comparing the patient groups and the healthy individuals in internally homogeneous layers for gender and age, as upper described. The intent is to define the significant molecules to select the c type of homeostatic biomarkers, indices of high-risk of disease, prognostic for the degeneration toward pathology.