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Figure 3 | Immunity & Ageing

Figure 3

From: Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses

Figure 3

SARS-CoV induced proinflammatory and antiviral cytokine expression differs in the lungs of aged compared to juvenile monkeys. Cytokines were measured in standardized-collected lung tissue homogenates from the right caudal lung lobe of both age groups by bead-based arrays in mock and SARS-CoV infected animals at 5 and 10 days post infection (d.p.i.). Levels of proinflammatory cytokines IL-1Beta (A) and IL-6 (B) as well as antiviral cytokines IL-12 (C), IL-15 (D), IL-18 (E), and IL-21 (F) were compared in aged and juvenile monkeys. Graphs represent average values (+/−SE) of cytokine in picograms per milliliter. *p < 0.05 in unpaired student T-test comparing juvenile and aged animals at the time points indicated by the horizontal bar.

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Immunity & Ageing

ISSN: 1742-4933

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