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Table 2 Cytokines and chemokines in serum of SARS-CoV infected aged and juvenile monkeys

From: Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses

  Concentration pg/ml cytokine +/− SE
Cytokine or chemokine Day 1 Day 5 Day 10 Statistics
  Juvenile Aged Juvenile Aged Juvenile Aged  
IL-1 ra 1.7 ± 1.3 12.0 + 3.1 59 ± 3.6 16.9 + 3.7 7.1 ± 3.9 6.7 ± 2.1 age p = 0.06
IL-8 156.0 ± 66.6 198.5 ± 81.4 200.2 ± 180.8 204.6 ± 98.5 151.1 ± 130.2 105.1 ± 73.7  
IL-12 34.1 ± 6.8 66.4 ± 15.0 37.5 ± 14.6 45.0 ± 21.2 24.4 ± 8.8 75.9 ± 42.1  
IL-15 2.2 ± 0.3 1.4 ± 0.3 3.9 ± 0.7 3.8 ± 1.2 4.0 ± 1.3 3.2 ± 0.4 d.p.i. *
IL-23 34.1 ± 6.8 58.1 ± 15.4 37.5 ± 14.6 45.0 ± 21.2 24.4 ± 8.8 75.9 ± 42.1  
IFN-y 0.7 ± 0.3 1.1 ± 0.3 1.6 ± 0.9 2.7 ± 0.8 2.5 ± 1.1 3.8 ± 2.6  
CCL2 1657.5 ± 129.5 1631.0 ± 463.9 3279.1 ± 619.9 1920.4 ± 535.5 1826.0 ± 5972 1160.0 ± 415.0 d.p.i. *
CCL3 2.6 ± 0.7 9.4 ± 2.3 2.1 ± 1.2 4.9 ± 2.9 0.5 ± 0.2 6.6 ± 2.1* age * , d.p.i. *
  1. Values represent picograms +/- standard error. Results of a 2-way ANOVA for age and days post infection (d.p.i.) are indicated at the right with asterisks denoting degree of significance p < 0.05. Significantly higher levels of cytokine at specific time points as determined by Bonferonni post tests are in bold.