Figure 5
From: Mycobacterium leprae Hsp65 administration reduces the lifespan of aged high antibody producer mice
Anti-Hsp65 and anti-DNA antibodies production in aged L III mice. Anti-Hsp65 IgG1 and IgG2a (A and C) and anti-DNA IgG1 and IgG2a (B and D) isotype production in the serum of aged LIII mice (4–8 animals/group, males and females) inoculated with WT, K409A Hsp65, or PBS (control). Antibody titers were determined by ELISA before (day 0) and after 7 and 14 days post-WT or -K409A Hsp65 inoculation. *p < 0.05, **p < 0.01 and ***p < 0.001 (Two-way ANOVA, Bonferroni multiple comparisons post-test).