Mycobacterium leprae Hsp65 administration reduces the lifespan of aged high antibody producer mice

Immunity & Ageing

Table 1 Mean survival time (days) and environmental variance of H _III and L _III mice

		♀ H_IIIadult	♀ H_IIIaged	♀ L_IIIaged	♂ H_IIIaged	♂ L_IIIaged
Control	MST	614 ± 177	531 ± 123	442 ± 72	469 ± 84	575 ± 97
	V_E	31473	15294	5329	7141	9534
		(n = 4)	(n = 6)	(n = 5)	(n = 6)	(n = 7)
WT	MST	466 ± 134*	308 ± 25**	615 ± 46**	403 ± 88	463 ± 141
	V_E	18182	635	2180	7802	20018
		(n = 4)	(n = 6)	(n = 5)	(n = 8)	(n = 8)
K ⁴⁰⁹ A	MST	665 ± 37	492 ± 61	442 ± 97	537 ± 151	496 ± 134
K ⁴⁰⁹ A	V_E	1422	3823	9591	23097	18093
		(n = 4)	(n = 5)	(n = 5)	(n = 7)	(n = 8)

Mean survival time (MST) and environmental variance (V_E) are shown for control, WT (native Hsp65) and K⁴⁰⁹A (mutant K⁴⁰⁹A Hsp65) injected mice groups, males (♂) and females (♀). The values are displayed as plus/minus standard deviation. The number of subject used for each treatment is indicated in parenthesis. *p < 0.05 and **p < 0.01 related to the control of each mice group.

ISSN: 1742-4933