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Figure 1 | Immunity & Ageing

Figure 1

From: Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells

Figure 1

The appearance of antigen-specific CD4 T cells in the lung airways after primary infection with influenza virus is delayed in aged mice. Young and aged mice were infected with 3,000 EID50 ×-31 influenza virus and the bronchoalveolar lavage (BAL) was assessed at 6, 8, 10, 12 and 14 days post infection for CD4 T cells and Flu NP-specific CD4 T cells. Panel A shows representative NP311–325/IAb tetramer staining. All data are gated on CD4 T cells. The number in the upper right of each plot indicates the per cent of tetramer+ cells among the activated (CD44high) CD4 T cells. Panel B shows the percent of CD4 T cells and the percent of NP311–325/IAb-specific cells in the BAL at the indicated timepoints after infection. Panel C shows the absolute number of CD4 T cells and NP311–325/IAb-specific cells in the BAL at the indicated timepoints after infection. The mean ± SD are shown and the data are representative of 2 independent experiments with 5–8 mice per time point. Data were analyzed by unpaired t-test (**p < 0.005).

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