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Table 2 Specific anti-PPS IgG antibody levels in young and elderly.

From: Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I Antibody concentrations, avidity and functional activity

Pre-immune serum GMC (95% CI)

  

CPS

CPS + 22F

P value

PPS4

Young

1.5 (0.59–2.41)

1.22 (0.77–1.66)

0.033

 

Elderly

1.94 (0.85–3.03)

1.39 (0.97–1.81)

0.008

PPS14

Young

3.86 (2.54–5.18)

4.02 (2.10–5.94)

0.370

 

Elderly

4.77 (1.61–7.93)

4.73 (2.42–7.04)

0.367

Post-immune serum GMC (95% CI)

  

CPS

CPS + 22F

P value

PPS4

Young

4.03 (1.68–6.38)

3.45 (1.62–5.28)

0.036

 

Elderly

3.95 (0.73–7.17)

3.50 (1.01–5.99)

0.142

PPS14

Young

18.41 (7.24–29.58)

18.43 (8.46–28.40)

0.708

 

Elderly

11.43 (4.44–18.42)

10.22 (3.35–17.09)

0.013

  1. Geometric mean concentration (GMC, μg/ml) of specific anti-PPS IgG antibody in pre-and post-immunization serum from young and elderly volunteers by two ELISA methods. CPS – serum adsorbed with CPS prior to ELISA. CPS+22F – serum absorbed with PPS22F and CPS prior to ELISA. P values shown in bold indicate significant difference between absorption methods by two tailed paired Student's T-test.