|
Pre-immune serum GMC (95% CI)
|
|---|
| | |
CPS
|
CPS + 22F
|
P value
|
|
PPS4
|
Young
|
1.5 (0.59–2.41)
|
1.22 (0.77–1.66)
|
0.033
|
| |
Elderly
|
1.94 (0.85–3.03)
|
1.39 (0.97–1.81)
|
0.008
|
|
PPS14
|
Young
|
3.86 (2.54–5.18)
|
4.02 (2.10–5.94)
|
0.370
|
| |
Elderly
|
4.77 (1.61–7.93)
|
4.73 (2.42–7.04)
|
0.367
|
|
Post-immune serum GMC (95% CI)
|
| | |
CPS
|
CPS + 22F
|
P value
|
|
PPS4
|
Young
|
4.03 (1.68–6.38)
|
3.45 (1.62–5.28)
|
0.036
|
| |
Elderly
|
3.95 (0.73–7.17)
|
3.50 (1.01–5.99)
|
0.142
|
|
PPS14
|
Young
|
18.41 (7.24–29.58)
|
18.43 (8.46–28.40)
|
0.708
|
| |
Elderly
|
11.43 (4.44–18.42)
|
10.22 (3.35–17.09)
|
0.013
|
- Geometric mean concentration (GMC, μg/ml) of specific anti-PPS IgG antibody in pre-and post-immunization serum from young and elderly volunteers by two ELISA methods. CPS – serum adsorbed with CPS prior to ELISA. CPS+22F – serum absorbed with PPS22F and CPS prior to ELISA. P values shown in bold indicate significant difference between absorption methods by two tailed paired Student's T-test.
