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Table 2 Specific anti-PPS IgG antibody levels in young and elderly.

From: Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I Antibody concentrations, avidity and functional activity

Pre-immune serum GMC (95% CI)
   CPS CPS + 22F P value
PPS4 Young 1.5 (0.59–2.41) 1.22 (0.77–1.66) 0.033
  Elderly 1.94 (0.85–3.03) 1.39 (0.97–1.81) 0.008
PPS14 Young 3.86 (2.54–5.18) 4.02 (2.10–5.94) 0.370
  Elderly 4.77 (1.61–7.93) 4.73 (2.42–7.04) 0.367
Post-immune serum GMC (95% CI)
   CPS CPS + 22F P value
PPS4 Young 4.03 (1.68–6.38) 3.45 (1.62–5.28) 0.036
  Elderly 3.95 (0.73–7.17) 3.50 (1.01–5.99) 0.142
PPS14 Young 18.41 (7.24–29.58) 18.43 (8.46–28.40) 0.708
  Elderly 11.43 (4.44–18.42) 10.22 (3.35–17.09) 0.013
  1. Geometric mean concentration (GMC, μg/ml) of specific anti-PPS IgG antibody in pre-and post-immunization serum from young and elderly volunteers by two ELISA methods. CPS – serum adsorbed with CPS prior to ELISA. CPS+22F – serum absorbed with PPS22F and CPS prior to ELISA. P values shown in bold indicate significant difference between absorption methods by two tailed paired Student's T-test.
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