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Table 3 Anti-PPS specific IgG isotype levels in young and elderly.

From: Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I Antibody concentrations, avidity and functional activity

  

Pre-immune, GMC (95% CI)

Post-immune GMC (95% CI)

P value

IgG1

    

PPS4

Young

0.13 (0.06)

0.35 (0.18)

0.001

 

Elderly

0.14 (0.09)

0.33 (0.38)

0.051

PPS14

Young

0.87 (0.13)

3.59 (0.33)

0.001

 

Elderly

0.93 (0.44)

1.19 (0.95)

0.015

IgG2

    

PPS4

Young

1.03 (0.37–1.69)

5.14 (0.64–9.64)

0.010

 

Elderly

0.83 (0.04–1.62)

1.96 (0.98–2.94)

0.005

PPS14

Young

2.18 (1.86–2.50)

12.33 (4.51–20.15)

0.002

 

Elderly

1.36 (0.62–2.10)

4.78 (2.37–7.19)

0.004

  1. Geometric mean concentration (GMC μg/ml) of anti-PPS antibody in pre-and post-immunization serum from young and elderly volunteers measured following absorption with CPS. P values shown in bold indicate significant difference between pre and post immunization by two tailed paired students T-test
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Immunity & Ageing

ISSN: 1742-4933

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