| | |
Pre-immune, GMC (95% CI)
|
Post-immune GMC (95% CI)
|
P value
|
|---|
|
IgG1
| | | | |
|
PPS4
|
Young
|
0.13 (0.06)
|
0.35 (0.18)
|
0.001
|
| |
Elderly
|
0.14 (0.09)
|
0.33 (0.38)
|
0.051
|
|
PPS14
|
Young
|
0.87 (0.13)
|
3.59 (0.33)
|
0.001
|
| |
Elderly
|
0.93 (0.44)
|
1.19 (0.95)
|
0.015
|
|
IgG2
| | | | |
|
PPS4
|
Young
|
1.03 (0.37–1.69)
|
5.14 (0.64–9.64)
|
0.010
|
| |
Elderly
|
0.83 (0.04–1.62)
|
1.96 (0.98–2.94)
|
0.005
|
|
PPS14
|
Young
|
2.18 (1.86–2.50)
|
12.33 (4.51–20.15)
|
0.002
|
| |
Elderly
|
1.36 (0.62–2.10)
|
4.78 (2.37–7.19)
|
0.004
|
- Geometric mean concentration (GMC μg/ml) of anti-PPS antibody in pre-and post-immunization serum from young and elderly volunteers measured following absorption with CPS. P values shown in bold indicate significant difference between pre and post immunization by two tailed paired students T-test
