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Table 3 Anti-PPS specific IgG isotype levels in young and elderly.

From: Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I Antibody concentrations, avidity and functional activity

   Pre-immune, GMC (95% CI) Post-immune GMC (95% CI) P value
IgG1     
PPS4 Young 0.13 (0.06) 0.35 (0.18) 0.001
  Elderly 0.14 (0.09) 0.33 (0.38) 0.051
PPS14 Young 0.87 (0.13) 3.59 (0.33) 0.001
  Elderly 0.93 (0.44) 1.19 (0.95) 0.015
IgG2     
PPS4 Young 1.03 (0.37–1.69) 5.14 (0.64–9.64) 0.010
  Elderly 0.83 (0.04–1.62) 1.96 (0.98–2.94) 0.005
PPS14 Young 2.18 (1.86–2.50) 12.33 (4.51–20.15) 0.002
  Elderly 1.36 (0.62–2.10) 4.78 (2.37–7.19) 0.004
  1. Geometric mean concentration (GMC μg/ml) of anti-PPS antibody in pre-and post-immunization serum from young and elderly volunteers measured following absorption with CPS. P values shown in bold indicate significant difference between pre and post immunization by two tailed paired students T-test
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