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Figure 2 | Immunity & Ageing

Figure 2

From: Life and death of lymphocytes: a role in immunesenescence

Figure 2

CD95-mediated Apoptosis. CD95 upon ligation with CD95 ligand (CD95L) undergo trimerization resulting in the recruitment of fas-associated death domain (FADD) and procaspase-8 to form death-inducing signaling complex (DISC). Procaspase-8 is autolytically activated by homodimerization and released from the DISC into the cytosol, where it cleaves and activate effector caspases to induce apoptosis.

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