Figure 6
From: The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging
Densitometric analyses of the expression of bcl-2 family member Bax in PMN with aging upon treatment with GM-CSF and PD98059 and SB203580 for 18 h as well as the ratio of the expression of Bax/Bcl-xL. Densitometric analysis were performed as described in the Materials and Methods section for the expression of Bax in neutrophils of young (white columns) and elderly subjects (black columns) under GM-CSF stimulation (A, *p < 0.01) and after the application of inhibitors, PD98059 (i-ERK) and SB203580 (i-p38) (B, p < 0.01). The ratio of Bax to Bcl-xL in PMN of young (white columns) and elderly subjects (black columns) under GM-CSF stimulation and modulation by inhibitors is represented (C).