Figure 2From: Innate immunity and inflammation in ageing: a key for understanding age-related diseasesAlzheimer's disease: amyloid deposition is one the main pathogenetic mechanism. Accumulation of Aβ peptide may be caused by 1) gene mutations (PS1, PS2 and APP human mutations in familial Alzheimer's disease) 2) genotype (and/or phenotype) favoring unbalanced inflammatory responses (pro-inflammatory genotype/anti-inflammatory genotype).Back to article page