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Table 5 Laboratory parameter elevationsSelected results, patients <45 years

From: Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers

PARAMETER Addicts† Medical† %'s* OR CI P
Age <45 Years 739/798 5834/11295 92.6%/51.7% 11.72 8.90–15.47 <0.0001
Body Mass Index >25 148/297 35/53 33.3%/39.8% 0.75 0.46–1.24 N.S.
CRP > 6 IU/l 81/73 490/811 52.6%/37.7% 1.84 1.30–2.60 <0.0005
ESR>30 mm/hr 13/155 49/1159 7.7%/4.1% 1.98 1.00–3.87 <0.05
Globulins >35. g/dl 90/519 503/4930 14.8%/9.3% 1.70 1.32–2.18 <0.0001
Albumin > 42 g/dl 345/264 3000/2433 56.7%/55.2% 1.06 0.89–1.26 N.S.
Globulin/Albumin Ratio >0.9 90/519 503/4930 14.8%/9.3% 1.69 1.21–2.21 <0.002
Albumin/Globulin Ratio >1.8 57/552 495/4938 9.4%/9.1% 1.03 0.76–1.39 N.S.
Lymphocytes >2.5 × 10(9)/l 224/377 1281/2748 37.3%/31.8% 1.27 1.06–1.53 <0.01
ALT > 90 IU/l 105/505 504/4920 17.2%/9.3% 2.03 1.60–2.57 <0.0001
Cholesterol > 4.2 mmol/l 347/263 3593/1872 56.9%/65.8% 0.67 0.56–0.80 <0.0001
Creatinine > 100 mcmol/l 59/679 272/5159 8.0%/5.0% 1.65 1.22–2.23 <0.001
Urea > 5 mmol/l 227/381 1588/3727 37.3%/29.9% 1.41 1.17–1.67 <0.0002
Urea/Creatinine Ratio >6.5 81/658 288/5140 11.0%/5.3% 2.78 2.11–3.65 <0.0001
Creatinine/Urea >22 134/605 1251/4177 18.1%/23.0% 0.74 0.60–0.91 <0.005
IGF1 >30 nmol/l 19/40 21/162 32.2%/11.5% 3.66 1.70–7.91 <0.0002
DHEAS >6 noml/l 30/40 57/109 42.9%/34.3% 1.54 0.78–2.64 N.S.
  1. † – Cells in these columns represent the numbers greater and less than the defined cut-off point.
  2. * – Relates to Percentages in Addicts Vs. Medical Patients