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Table 1 Some biological and immune parameters in young (A), old (B) and very old mice (C) during the circadian cycle and during partial hepatectomy/liver regeneration. A parallelism with old and centenarians is reported.

From: Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans

  MICE   HUMANS
  Circadian Cycle   Partial Hepatectomy   Old Centenarians
   LP DP    0 h 48 h 15 gg    
Number of NKTγδ cells A ++ + MT A - +++ - MT + -
  B -- --   B + + +    
  C + ++   C - + -    
NKT cell cytotoxicity A ++ +++ NKT cell cytotoxicity A ++ - ++ NKT cell cytotoxicity - +
  B -- --   B - - -    
  C + ++   C + - +    
IFNγ A + ++ Thymic endocrine activity A ++ - ++ IFNγ - +
  B - -   B - - -    
  C + ++   C + - +    
IL-2 A + ++ IL-2 A ++ - ++ IL-6 ++ ++
  B - -   B - - - gp 130 ++ -
  C + ++   C + - +    
Plasma zinc A + ++ Plasma Zinc A ++ - ++ Plasma zinc - +
  B - -   B - - -    
  C + ++   C + - +    
  1. + = satisfactory ++ = high +++ = very high - = low -- = very low
  2. LP = Light Period DP = Dark Period