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Table 1 Some biological and immune parameters in young (A), old (B) and very old mice (C) during the circadian cycle and during partial hepatectomy/liver regeneration. A parallelism with old and centenarians is reported.

From: Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans

 

MICE

 

HUMANS

 

Circadian Cycle

 

Partial Hepatectomy

 

Old

Centenarians

  

LP

DP

  

0 h

48 h

15 gg

   

Number of NKTγδ cells

A

++

+

MT

A

-

+++

-

MT

+

-

 

B

--

--

 

B

+

+

+

   
 

C

+

++

 

C

-

+

-

   

NKT cell cytotoxicity

A

++

+++

NKT cell cytotoxicity

A

++

-

++

NKT cell cytotoxicity

-

+

 

B

--

--

 

B

-

-

-

   
 

C

+

++

 

C

+

-

+

   

IFNγ

A

+

++

Thymic endocrine activity

A

++

-

++

IFNγ

-

+

 

B

-

-

 

B

-

-

-

   
 

C

+

++

 

C

+

-

+

   

IL-2

A

+

++

IL-2

A

++

-

++

IL-6

++

++

 

B

-

-

 

B

-

-

-

gp 130

++

-

 

C

+

++

 

C

+

-

+

   

Plasma zinc

A

+

++

Plasma Zinc

A

++

-

++

Plasma zinc

-

+

 

B

-

-

 

B

-

-

-

   
 

C

+

++

 

C

+

-

+

   
  1. + = satisfactory ++ = high +++ = very high - = low -- = very low
  2. LP = Light Period DP = Dark Period