Figure 1From: Immunity, ageing and cancerImpact of ageing on immune cell development. Genetic and environmental influences modulate age-associated alterations to the number and function of HSCs in the BM, resulting in skewed production of leukocytes. Reduced production of T cell progenitors, together with age-associated thymic involution, results in a relatively larger impact of age on T cells than on other leukocytes.Back to article page